Rédacteur : Johan Nguyen
Sommaire
chemotherapy-induced nausea and vomiting
Nausées-vomissements chimio-induits
1. Systematic Reviews and Meta-Analysis
1.1. Generic Acupuncture
1.1.1. Wang 2025 (network Meta-analysis)
Wang Y, Wang F, Hu F, Long F. Effect of non-pharmacological interventions on chemotherapy induced delayed nausea and vomiting for tumors: a systematic review and Bayesian network Meta-analysis. Complement Ther Med. 2025 Jan 9:103124. https://doi.org/10.1016/j.ctim.2024.103124
| Objective | To evaluate the efficacy of non-pharmacological interventions in improving chemotherapy induced delayed nausea and vomiting symptoms using a network meta-analysis. |
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| Methods | Four Chinese databases (CNKI, Wanfang Data Knowledge Service Platform, VIP, Sinomed) and five English databases (PubMed, Cochrane Library, Embase, Web of Science, CINAHL) were searched from the establishment of the database to April 2024. A Bayesian network meta-analysis was performed on the response rate to the improvement of chemotherapy induced delayed nausea and vomiting, as well as improvement in KPS score, under different non-pharmacological interventions by using R 4.1.3 software and the GeMTC package. |
| Results | A total of 58 RCTs 4081 patients were selected，involving 14 non-pharmacological interventions. The results of Meta-analysis showed that acupoint patch was identified as the most probable superior intervention in the improvement of chemotherapy induced delayed nausea and vomiting, and acupuncture was identified as the most probable superior intervention on the improvement of KPS scores. |
| Conclusion | Non-pharmacological interventions can serve as an effective complementary approach to managing delayed chemotherapy-induced nausea and vomiting. In particular, acupoint application may be the optimal complementary therapy to mitigate the incidence of delayed nausea and vomiting, though more high-quality, large-scale evidence is required to conclusively demonstrate the efficacy of acupuncture in enhancing the quality of life for cancer patients. |
1.1.2. Yan 2023 ★
Yan Y, López-Alcalde J, Zhang L, Siebenhüner AR, Witt CM, Barth J. Acupuncture for the prevention of chemotherapy-induced nausea and vomiting in cancer patients: A systematic review and meta-analysis. Cancer Med. 2023 Jun;12(11):12504-12517. https://doi.org/10.1002/cam4.5962
| Purpose | To assess the effectiveness and safety of acupuncture for the prevention of chemotherapy-induced nausea and vomiting (CINV), with a specific intention on exploring sources of between-study variation in treatment effects. |
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| Methods | MEDLINE, EMBASE, Cochrane CENTRAL, CINAHL, Chinese Biomedical Literature Database, VIP Chinese Science and Technology Periodicals Database, China National Knowledge Infrastructure, and Wanfang were searched to identify randomized controlled trials (RCTs) that compared acupuncture to sham acupuncture or usual care (UC). The main outcome is complete control (no vomiting episodes and/or no more than mild nausea) of CINV. GRADE approach was used to rate the certainty of evidence. |
| Results | Thirty-eight RCTs with a total of 2503 patients were evaluated. Acupuncture in addition to UC may increase the complete control of acute vomiting (RR, 1.13; 95% CI, 1.02 to 1.25; 10 studies) and delayed vomiting (RR, 1.47; 95% CI, 1.07 to 2.00; 10 studies) when compared with UC only. No effects were found for all other review outcomes. The certainty of evidence was generally low or very low. None of the predefined moderators changed the overall findings, but in an exploratory moderator analysis we found that an adequate reporting of planned rescue antiemetics might decrease the effect size of complete control of acute vomiting (p = 0.035). |
| Conclusion | Acupuncture in addition to usual care may increase the complete control of chemotherapy-induced acute vomiting and delayed vomiting but the certainty of evidence was very low. Well-designed RCTs with larger sample sizes, standardized treatment regimens, and core outcome measures are needed. |
1.1.3. Lian 2014 ☆☆
Lian WL, Pan MQ, Zhou DH, Zhang ZJ. Effectiveness of acupuncture for palliative care in cancer patients: a systematic review. Chin J Integr Med. 2014.20(2):136-47. [160304].
| Objective | To critically evaluate the currently available randomized clinical trials regarding the effectiveness of acupuncture in palliative care for cancer patients, hence, to provide sufficient evidences for the widespread use of acupuncture in cancer treatment. |
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| Methods | Two independent reviewers extracted data from all of the randomized clinical trials (RCTs) that assessed the efficacy of acupuncture in palliative care for cancer patients. Seven databases were searched from their respective inception to December 2010. All eligible trials identified were evaluated by two independent reviewers using the Jadad scale, and data from the articles were validated and extracted. |
| Results | In total, 33 RCTs met the inclusion criteria. The effects of acupuncture on different cancer-related aspects were shown, including chemotherapy or radiotherapy-induced side effects (13/33, 39.4%), cancer pain (6/33, 18.2%), post-operative urinary retention (4/33, 12.1%), quality of life (2/33, 6.1%), vasomotor syndrome (2/33, 6.1%), post-operative gastrointestinal dysfunction (2/33, 6.1%), prevention of prolonged postoperative ileus (2/33, 6.1%), joint symptoms (1/33, 3.0%), and immunomodulation (1/33, 3.0%). |
| Conclusions | The result of our systematic review suggested that the effectiveness of acupuncture in palliative care for cancer patients is promising, especially in reducing chemotherapy or radiotherapy-induced side effects and cancer pain. Acupuncture may be an appropriate adjunctive treatment for palliative care. |
1.1.4. Mckeon 2013 ☆☆
Mckeon C, Smith CA, Hardy J, Chang E. Acupuncture and acupressure for chemotherapy-induced nausea and vomiting: a systematic review. Aust J Acupunct Chin Med. 2013. 8(1):2-27. [160092].
| Background | Control of chemotherapy-induced nausea and vomiting (CINV) has improved with advances in antiemetics, such as NK1 antagonists. Despite these advances, patients still experience these symptoms, and expert panels encourage additional methods to reduce these symptoms. |
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| Objectives | The objective was to assess the effectiveness of acupuncture and acupressure on acute and delayed CINV in cancer patients. |
| Methods | Search strategy: The following databases were searched: AMED, MEDLINE, CINAHL, PubMed, Cochrane Controlled Trials Registry, and Science Direct. The search was undertaken from the inception of the database to January 2012. Selection criteria: Randomised controlled trials and systematic reviews of acupoint stimulation by needles, electrical stimulation or acupressure (excluding laser, point injection and non-invasive electrostimulation) and assessing chemotherapy-induced nausea or vomiting, or both. Data collection and analysis: Data was provided by publications of original trials and pooled. Standardised mean differences with confidence incidences were calculated. |
| Main results | Seven trials were pooled for acupuncture and six for acupressure. Acupuncture reduced the frequency of acute vomiting (mean difference [MD] -7.40, 95% confidence interval [CI] -9.07 to -5.72), but did not reduce acute nausea severity or frequency compared to control. Delayed symptoms for acupuncture were not reported. Acupuncture showed a reduction in the dose of rescue medication (MD -5.52, 95% CI -7.45 to -3.58). Acupressure showed a decrease in frequency of nausea (MD -0.32, 95% CI -0.59 to 0.06) but not acute vomiting or delayed symptoms. All trials used state-of-the-art combination antiemetics, except for the early electroacupuncture trials. |
| Authors’ conclusions | Acupuncture has demonstrated some benefit for chemotherapy-induced acute vomiting by reducing the frequency of vomiting and reducing the use of rescue medication, while acupressure has shown a decrease in the frequency of nausea. Further trials of acupuncture and acupressure for chemotherapy-induced nausea and vomiting in patients with refractory symptoms are needed before recommendations for clinical practice can be made. Future trials must be sufficiently powered, as this remains a major flaw with the majority of studies to date. |
1.1.5. Garcia 2013 ☆
Garcia MK, Mcquade J, Haddad R, Patel S, Lee R, Yang P, Palmer JL, Cohen L. Systematic review of acupuncture in cancer care: a synthesis of the evidence. J Clin Oncol. 2013. 31(7):952-60. [157620].
| Purpose | Many cancer centers offer acupuncture services. To date, a comprehensive systematic review of acupuncture in cancer care has not been conducted. The purpose of this review was to evaluate the efficacy of acupuncture for symptom management in patients with cancer. |
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| Methods | Medline, Embase, CINAHL, Cochrane (all databases), Scopus, and PubMed were searched from inception through December 2011 for prospective randomized clinical trials (RCT) evaluating acupuncture for symptom management in cancer care. Only studies involving needle insertion into acupuncture points were included. No language limitations were applied. Studies were assessed for risk of bias (ROB) according to Cochrane criteria. Outcomes by symptom were designated as positive, negative, or unclear. |
| Results | A total of 2,151 publications were screened. Of those, 41 RCTs involving eight symptoms (pain, nausea, hot flashes, fatigue, radiation-induced xerostomia, prolonged postoperative ileus, anxiety/mood disorders, and sleep disturbance) met all inclusion criteria. One positive trial of acupuncture for chemotherapy-induced nausea and vomiting had low ROB. Of the remaining studies, eight had unclear ROB (four positive, three negative, and one with unclear outcomes). Thirty-three studies had high ROB (19 positive, 11 negative, and three with both positive and negative outcomes depending on the symptom). |
| Conclusion | Acupuncture is an appropriate adjunctive treatment for chemotherapy-induced nausea/vomiting, but additional studies are needed. For other symptoms, efficacy remains undetermined owing to high ROB among studies. Future research should focus on standardizing comparison groups and treatment methods, be at least single-blinded, assess biologic mechanisms, have adequate statistical power, and involve multiple acupuncturists. |
1.1.6. Silva 2009 ☆☆
Silva, Dacirene Ribeiro França; Reis, Paula Elaine Diniz; Gomes, Isabelle Pimentel Gomes; Funghetto, Silvana Schwerz; Ponce de Leon, Casandra G. R. M. [Non Pharmacological Interventions for Chemotherapy Induced Nauseas and Vomits: integrative review]. Online Brazilian Journal of Nursing. 2009;8(1):. [99711].
| Background | Nausea and vomiting are one of the most common gastrointestinal toxicities of antineoplastic treatment; it may affect negatively patient`s nutritional condition, hidroeletrolitic balance and quality of life. |
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| Objective methods | This study aimed to identify evidences in medical literature regarding non-pharmacologic interventions to prevent and treat chemotherapy induced nausea and vomiting. We performed an integrative review on online databases for that purpose. |
| Results | We elected 9 articles from this research, which presented the following possible non-pharmacological interventions for chemotherapy emesis: acupressure, acupuncture, electroacupuncture, relaxing techniques and yoga. |
| Conclusions | The authors concluded that the results suggested that these interventions should be recommended for cancer patients, mainly those presenting chemotherapy emesis in consecutive cycles. |
1.1.7. Ezzo 2006 ☆☆
Ezzo JM, Richardson MA, Vickers A, Allen C, Dibble SL, Issell BF, Lao L, Pearl M, Ramirez G, Roscoe J, Shen J, Shivnan JC, Streitberger K, Treish I, Zhang G. Acupuncture-point stimulation for chemotherapy-induced nausea or vomiting. Cochrane Database Syst Rev. 2006;(2):CD002285.141212
| Purpose | The objective was to assess the effectiveness of acupuncture-point stimulation on acute and delayed chemotherapy-induced nausea and vomiting in cancer patients. |
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| Methods | Search strategy : We searched MEDLINE, EMBASE, PsycLIT, MANTIS, Science Citation Index, CCTR (Cochrane Controlled Trials Registry), Cochrane Complementary Medicine Field Trials Register, Cochrane Pain, Palliative Care and Supportive Care Specialized Register, Cochrane Cancer Specialized Register, and conference abstracts. Selection criteria: randomized trials of acupuncture-point stimulation by any method (needles, electrical stimulation, magnets, or acupressure) and assessing chemotherapy-induced nausea or vomiting, or both. Data collection and analysis: Data were provided by investigators of the original trials and pooled using a xed effect model. Relative risks were calculated on dichotomous data. Standardized mean differences were calculated for nausea severity. Weighted mean differences were calculated for number of emetic episodes. |
| Results | Eleven trials (N = 1247) were pooled. Overall, acupuncture-point stimulation of all methods combined reduced the incidence of acute vomiting (RR = 0.82; 95% con dence interval 0.69 to 0.99; P = 0.04), but not acute or delayed nausea severity compared to control. By modality, stimulation with needles reduced proportion of acute vomiting (RR = 0.74; 95% con dence interval 0.58 to 0.94; P = 0.01),but not acute nausea severity. Electroacupuncture reduced the proportion of acute vomiting (RR = 0.76; 95% con dence interval 0.60 to 0.97; P = 0.02), but manual acupuncture did not; delayed symptoms for acupuncture were not reported. Acupressure reduced mean acute nausea severity (SMD = -0.19; 95% con dence interval -0.37 to -0.01; P = 0.04) but not acute vomiting or delayed symptoms. Noninvasive electrostimulation showed no bene t for any outcome. All trials used concomitant pharmacologic antiemetics, and all, except electroacupuncture trials, used state-of-the-art antiemetics. |
| Conclusion | This review complements data on post-operative nausea and vomiting suggesting a biologic effect of acupuncture-point stimulation. Electroacupuncture has demonstrated benefit for chemotherapy-induced acute vomiting, but studies combining electroacupuncture with state-of-the-art antiemetics and in patients with refractory symptoms are needed to determine clinical relevance. Self-administered acupressure appears to have a protective effect for acute nausea and can readily be taught to patients though studies did not involve placebo control. |
1.1.8. Ezzo 2005 ☆☆
Ezzo J, Vickers A, Richardson MA, Allen C, Dibble SL, Issell B, Lao L, Pearl M, Ramirez G, Roscoe Ja, Shen J, Shivnan J, Streitberger K, Treish I, Zhang G. Acupuncture-point stimulation for chemotherapy-induced nausea and vomiting. J Clin Oncol. 2005. 23(28):7188-98. [140957].
| Purpose | Assess the effectiveness of acupuncture-point stimulation on acute and delayed chemotherapy-induced nausea and vomiting in cancer patients. |
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| Materials and methods | Randomized trials of acupuncture-point stimulation by needles, electrical stimulation, magnets, or acupressure were retrieved. Data were provided by investigators of the original trials and pooled using a fixed-effects model. |
| Results | Eleven trials (N = 1,247) were pooled. Overall, acupuncture-point stimulation reduced the proportion of acute vomiting (relative risks [RR] = 0.82; 95% CI, 0.69 to 0.99; P = .04), but not the mean number of acute emetic episodes or acute or delayed nausea severity compared with controls. By modality, stimulation with needles reduced the proportion of acute vomiting (RR = 0.74; 95% CI, 0.58 to 0.94; P = .01), but not acute nausea severity. Electroacupuncture reduced the proportion of acute vomiting (RR = 0.76; 95% CI, 0.60 to 0.97; P = .02), but manual acupuncture did not; delayed symptoms were not reported. Acupressure reduced mean acute nausea severity (standardized mean difference = -0.19; 95% CI, -0.38 to -0.01; P = .03) and most severe acute nausea, but not acute vomiting or delayed symptoms. Noninvasive electrostimulation showed no benefit for any outcome. All trials used concomitant pharmacologic antiemetics, and all, except electroacupuncture trials, used state-of-the-art antiemetics. |
| Conclusion | This review complements data on postoperative nausea and vomiting, suggesting a biologic effect of acupuncture-point stimulation. Electroacupuncture has demonstrated benefit for chemotherapy-induced acute vomiting, but studies with state-of-the-art antiemetics as well as studies for refractory symptoms are needed to determine clinical relevance. Acupressure seems to reduce chemotherapy-induced acute nausea severity, though studies did not involve a placebo control. Noninvasive electrostimulation seems unlikely to have a clinically relevant impact when patients are given state-of-the-art pharmacologic antiemetic therapy. |
1.2. Special Acupuncture Techniques
1.2.1. Moxibustion
1.2.1.1. Yao 2022
Yao Z, Xu Z, Xu T, Liu X, Xu S, Wan C, Zhou X. Moxibustion for alleviating chemotherapy-induced gastrointestinal adverse effects: A systematic review of randomized controlled trials. Complement Ther Clin Pract. 2022 Feb;46:101527. https://doi.org/10.1016/j.ctcp.2021.101527
| Objective | This systematic review aims to assess whether moxibustion is effective and safe for gastrointestinal adverse effects, a common and thorny issue arising from chemotherapy. |
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| Methods | Seven electronic databases were searched up to August 28, 2021, to identify randomized controlled trials (RCTs) comparing moxibustion versus non-moxibustion treatments for various gastrointestinal adverse effects after chemotherapy. The Karnofsky performance status (KPS) and quality of life scores and the incidence of moxibustion-related adverse events were also investigated. Effects in meta-analyses were measured by risk ratios (RRs) or mean differences (MDs). |
| Results | Thirty-two RCTs (n = 2990) were included. Compared to the controls, moxibustion significantly reduced the incidences of nausea/vomiting (RR 0.70, 95% CI 0.61-0.79), severe nausea/vomiting (RR 0.39, 95% CI 0.29-0.51), diarrhoea (RR 0.56, 95% CI 0.38-0.82), constipation (RR 0.59, 95% CI 0.44-0.78), and abdominal distension (RR 0.60, 95% CI 0.46-0.78). The KPS (MD 7.53, 95% CI 3.42-11.64) and quality of life (MD 8.88, 95% CI 0.96-16.80) scores were also significantly improved after moxibustion. The results did not support a benefit of moxibustion on inappetence (RR 0.69, 95% CI 0.40-1.22) or abdominal pain (RR 0.60, 95% CI 0.28-1.30). All adverse events related to moxibustion were mild. |
| Conclusions | Moderate-to very-low-quality evidence suggests that moxibustion may be safely used as an adjuvant treatment after chemotherapy to reduce the incidences of nausea and vomiting, diarrhoea, constipation, and abdominal distension and improve the performance status and quality of life in patients with malignant tumours. Its effects on abdominal pain and inappetence are uncertain. |
1.2.1.2. Zhang 2018
Zhang HW, Lin ZX, Cheung F, Cho WC, Tang JL. Moxibustion for alleviating side effects of chemotherapy or radiotherapy in people with cancer. Cochrane Database Syst Rev. 2018:112p. [196416]. doi
| Background | Moxibustion, a common treatment in traditional Chinese medicine, involves burning herbal preparations containing Artemisia vulgaris on or above the skin at acupuncture points. Its intended effect is to enhance body function, and it could reduce the side effects of chemotherapy or radiotherapy and improve quality of life (QoL) in people with cancer. |
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| Objectives | To assess the effects of moxibustion for alleviating side effects associated with chemotherapy, radiotherapy or both in people with cancer. |
| Methods | SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL) in the Cochrane Library, MEDLINE via Ovid, Embase via Ovid and AMED (Allied and Complementary Medicine Database) from their inception to February 2018. We also searched databases in China including the Chinese BioMedical Literature Database (CBM), Chinese Medical Current Contents (CMCC), TCMonline, Chinese Dissertation Database (CDDB), China Medical Academic Conference (CMAC) and Index to Chinese Periodical Literature from inception to August 2017. Registries for clinical trials and other resources were also searched. SELECTION CRITERIA: We included randomised controlled trials (RCTs) comparing moxibustion treatment, including moxa cone and moxa stick, versus sham, no treatment or conventional treatment. DATA COLLECTION AND ANALYSIS: Two review authors (HWZ and FC) independently extracted data on study design, participants, treatment and control intervention, and outcome measures, and they also assessed risk of bias in the included studies. We performed meta-analyses, expressing dichotomous outcomes as risk ratios (RR) and continuous outcomes as mean differences (MD), with 95% confidence intervals (CI). |
| Main results | We included 29 RCTs involving 2569 participants. Five RCTs compared moxibustion versus no treatment, 15 compared moxibustion plus conventional treatment versus conventional treatment, one compared moxibustion versus sham moxibustion, and eight compared moxibustion versus conventional medicine. The overall risk of bias was high in 18 studies and unclear in 11 studies. Studies measured outcomes in various ways, and we could rarely pool data. Moxibustion versus no treatment: low-certainty evidence from single small studies suggested that moxibustion was associated with higher white blood cell counts (MD 1.77 × 109/L; 95% CI 0.76 to 2.78; 80 participants, low-certainty evidence) and higher serum haemoglobin concentrations (MD 1.33 g/L; 95% CI 0.59 to 2.07; 66 participants, low-certainty evidence) in people with cancer, during or after chemotherapy/radiotherapy, compared with no treatment. There was no evidence of an effect on leukopenia (RR 0.50, 95% CI 0.10 to 2.56; 72 participants, low-certainty evidence) between study groups. The effects on immune function (CD3, CD4, and CD8 counts) were inconsistent. Moxibustion versus sham moxibustion: low-certainty evidence from one study (50 participants) suggested that moxibustion improved QoL (measured as the score on the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-C30 (EORTC QLQ-C30)) compared with sham treatment (MD 14.88 points; 95% CI 4.83 to 24.93). Low-certainty evidence from this study also showed reductions in symptom scores for nausea and vomiting (MD -38.57 points, 95% CI -48.67 to -28.47) and diarrhoea (MD -13.81, 95% CI -27.52 to -0.10), and higher mean white blood cell count (MD 1.72 × 109/L, 95% CI 0.97 to 2.47), serum haemoglobin (MD 2.06 g/L, 95% CI 1.26 to 2.86) and platelets (MD 210.79 × 109/L, 95% CI 167.02 to 254.56) when compared with sham moxibustion. Moxibustion versus conventional medicines: low-certainty evidence from one study (90 participants) suggested that moxibustion improved WBC count eight days after treatment ended compared with conventional medicines (MD 0.40 × 109/L; 95% CI 0.15 to 0.65). Low-certainty evidence from two studies (235 participants) suggested moxibustion improved serum haemoglobin concentrations compared with conventional medicines (MD 10.28 g/L; 95% CI 4.51 to 16.05).Moxibustion plus conventional treatment versus conventional treatment alone: low-certainty evidence showed that moxibustion plus conventional treatment was associated with lower incidence and severity of leukopenia (WHO grade 3 to 4) (RR 0.14, 95% CI 0.01 to 2.64; 1 study, 56 participants), higher QoL scores on the EORTC QLQ-C30 (MD 8.85 points, 95% CI 4.25 to 13.46; 3 studies, 134 participants, I² = 26%), lower symptom scores for nausea and vomiting (RR 0.43, 95% CI 0.25 to 0.74; 7 studies, 801participants; I² = 19%), higher white blood cell counts (data not pooled due to heterogeneity), higher serum haemoglobin (MD 3.97 g/L, 95% CI 1.40 to 6.53; 2 studies, 142 participants, I² = 0%). There was no difference in platelet counts between the two groups (MD 13.48 × 109/L; 95% CI -16.00 to 42.95; 2 studies, 142 participants; I² = 34%).Most included studies did not report related adverse events, such as burning or allergic reactions. |
| Authors' conclusions | Limited, low-certainty evidence suggests that moxibustion treatment may help to reduce the haematological and gastrointestinal toxicities of chemotherapy or radiotherapy, improving QoL in people with cancer; however, the evidence is not conclusive, and we cannot rule out benefits or risks with this treatment. High-quality studies that report adverse effects are needed. |
1.2.1.3. Huang 2017 Ø
Huang Z, Qin Z, Yao Q, Wang Y, Liu Z. Moxibustion for Chemotherapy-Induced Nausea and Vomiting: A Systematic Review and Meta-Analysis. Evid Based Complement Alternat Med. 2017. [49920].
| Background | Nausea and vomiting are distressing symptoms for patients receiving chemotherapy. Moxibustion, which involves the use of burning moxa to generate heat and stimulate acupoints, has been reported to potentially ameliorate chemotherapy-induced side effects, particularly nausea and vomiting. |
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| Objectives | This systematic review evaluated current evidence on the effectiveness of moxibustion against chemotherapy-induced nausea and vomiting (CINV). |
| Methods | We searched eight online databases and two trial registries for relevant trials. The random-effects model was used to conduct a meta-analysis. Furthermore, the risk ratio (RR) and mean difference (MD) were used to explain dichotomous and continuous outcomes, respectively; the outcomes were within 95% confidence intervals (Cis). |
| Results | The results revealed that moxibustion might more favorably relieve the severity and frequency of CINV, compared with no treatment (RR: 2.04, 95% CI: 1.42-2.93); moxibustion might have stronger effects than antiemetic drugs (RR: 1.87, 95% CI: 1.27-2.76). There is no robust result that moxibustion could enhance the effects of antiemetic drugs administered as a complementary treatment. Actual moxibustion (8.10 ± 10.98) may have more favorable effects than placebo moxibustion (46.67 ± 23.32). |
| Conclusions | However, the evidence obtained is not sufficient because of the lack of strict clinical trials. |
1.2.2. Acupression
1.2.2.1. Lee 2008 ☆
Lee J, Dodd M, Dibble S, Abrams D. Review of acupressure studies for chemotherapy-induced nausea and vomiting control. J Pain Symptom Manage. 2008. 36(5):529-44. [159369].
| Objective | The purpose of this review was to evaluate the effects of a noninvasive intervention, acupressure, when combined with antiemetics for the control of chemotherapy-induced nausea and vomiting (CINV). |
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| methods – results | Ten controlled acupressure studies were included in this review. The review evaluated one quasi-experimental and nine randomized clinical trials, which included two specific acupressure modalities, that is, acupressure band and finger acupressure. The effects of the acupressure modalities were compared study by study. Four of seven acupressure band trials supported the positive effects of acupressure, whereas three acupressure band trials yielded negative results regarding the possible effects of acupressure; however, all the studies with negative results had methodological issues. In contrast, one quasi-experimental and two randomized finger acupressure trials all supported the positive effects of acupressure on CINV control. The reported effects of the two acupressure modalities in each phase of CINV produced variable results. Acupressure bands were effective in controlling acute nausea, whereas finger acupressure controlled delayed nausea and vomiting. The overall effect of acupressure was strongly suggestive but not conclusive. Differences in the acupressure modality, the emetic potential of chemotherapeutic agents, antiemetic use, and sample characteristics of each study made study-to-study comparisons difficult. Suggestive effects of acupressure, cost-effectiveness, and the noninvasiveness of the interventions encourage researchers to further investigate the efficacy of this modality. |
| Conclusions | Acupressure should be strongly recommended as an effective, nonpharmacologic adjuvant intervention for CINV control if its positive effects are reproduced in future acupressure clinical trials. |
1.2.2.2. Klein 2004 ☆
Klein J, Griffiths P. Acupressure for nausea and vomiting in cancer patients receiving chemotherapy, British Journal of Community Nursing. 2004. 9(9):383-88. [159378].
| Background | Practitioners working with patients undergoing chemotherapy regularly encourage them to use acupressure in the form of Sea Bands™ for the relief of treatment related nausea and vomiting. This mini-review sets out to uncover and examine the evidence base for this recommendation. |
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| Objective | A mini systematic review was carried out to identify randomized controlled trials comparing the use of acupressure plus usual care with usual care alone. The population was adult patients receiving cancer chemotherapy. The outcome was nausea or vomiting duration or intensity. |
| Methods | Searches on Medline, Embase, AMED, the Cochrane Library, Cancerlit and Cinahl identified two randomized controlled trials involving 482 patients which compared acupressure to no intervention control. |
| Results / conclusion | The results suggest that acupressure may decrease nausea among patients undergoing chemotherapy but further work is required before conclusively advising patients on the efficacy of acupressure in preventing and treating chemotherapy induced nausea. |
1.2.3. Acupoint injection
1.2.3.1. Ai 2024
Ai M, Cai Y, Zeng Y, Xiong D. Efficacy of acupoint injection of metoclopramide for post-chemotherapy vomiting: A systematic review and meta-analysis. Medicine (Baltimore). 2024 Apr 5;103(14):e37569. https://doi.org/10.1097/MD.0000000000037569
| Backgound | Vomiting is one of the most common adverse events of chemotherapy. The purpose of this study was to systematically review the clinical efficacy of acupoint injection of metoclopramide in the treatment of post-chemotherapy vomiting. |
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| Methods | We searched 4 general English databases and 4 conventional Chinese databases, all with a time frame from database creation to December 2022. The retrieved clinical trials of acupoint injection of metoclopramide for post-chemotherapy vomiting were then subjected to meta-analysis and trial sequential analysis. |
| Results | A total of 12 studies were included, with a total sample size of 965 cases. Meta-analysis showed that acupoint injection of metoclopramide was effective in improving anti-vomiting effective rate [odds ratio = 5.67, 95% confidence interval = (3.80,8.47), P < .00001] compared with intramuscular/intravenous injection, and trial sequential analysis showed that this benefit was conclusive. Subgroup analysis demonstrated that acupoint injection significantly improved the anti-vomiting effective rate at doses of 10 mg qd, 20 mg qd, and 30 mg qd, as well as at durations of 1 day and 5 days. Subgroup analysis also indicated that injection at the Zusanli acupoint significantly increased the anti-vomiting effective rate, while injection at the Neiguan acupoint had an anti-vomiting effective rate comparable to that of the control group. Harbord regression showed no significant publication bias (P = .730). |
| Conclusion | Acupoint injection of metoclopramide for post-chemotherapy vomiting is more effective than intramuscular and intravenous injections and is not limited by dose or duration of treatment, which may be the preferred way of administration. |
1.3. Special Clinical Forms
1.3.1. Children
1.3.1.1. Mora 2022
Mora DC, Overvåg G, Jong MC, Kristoffersen AE, Stavleu DC, Liu J, Stub T. Complementary and alternative medicine modalities used to treat adverse effects of anti-cancer treatment among children and young adults: a systematic review and meta-analysis of randomized controlled trials. BMC Complement Med Ther. 2022 Apr 2;22(1):97. https://doi.org/10.1186/s12906-022-03537-w
| Background | Dealing with the symptom burden of cancer diagnosis and treatment has led parents to seek different self-management strategies including Alternative and Complementary Medicine (CAM). The aim of this study was to perform a systematic review and meta-analysis about the use and effect of CAM modalities to treat adverse effects of conventional cancer treatment among children and young adults. |
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| Methods | Six scientific research databases were used to identify randomized controlled trials (RCTs) from 1990 to September 2020. Included studies investigated the use of CAM to treat cancer treatment related adverse effects in children and young adults compared to controls. |
| Results | Twenty RCTs comprising 1,069 participants were included in this review. The included studies investigated acupuncture, mind-body therapies, supplements, and vitamins for chemotherapy-induced nausea and vomiting (CINV), oral mucositis, and anxiety among children and young adults who underwent conventional cancer treatment. Seven studies (315 participants) were included in the meta-analysis. The overall effect of CAM (including acupuncture and hypnosis only) on chemotherapy-induced nausea and/or vomiting and controls was statistically significant with a standard mean difference of -0.54, 95% CI [-0.77, -0.31] I2 = 0% (p < 0.00001). There was a significant difference between acupuncture and controls (n = 5) for intensity and/or episodes of CINV with an SMD -0.59, 95% CI [-0.85, -0.33] (p < 0.00001). No significant difference was found between hypnosis and controls (n = 2) for severity or episodes of CINV with an SMD -0.41, 95% CI [-1.09, 0.27] I2 = 41% (p = 0.19). |
| Conclusion | Current evidence from this meta-analysis of randomized controlled trials shows that CAM, including acupuncture and hypnosis only, is effective in reducing chemotherapy-induced nausea and vomiting in children and young adults. More rigorous trials and long-term effects should be investigated if acupuncture and hypnosis are to be recommended for clinical use. |
1.3.1.2. Momani 2017 ∼
Momani TG, Berry DL. Integrative Therapeutic Approaches for the Management and Control of Nausea in Children Undergoing Cancer Treatment: A Systematic Review of Literature. J Pediatr Oncol Nurs. 2017;:173-184. [194926].
| Objectives | Chemotherapy-induced nausea and vomiting (CINV) continues to be a common symptom experienced by children undergoing cancer treatment despite the use of contemporary antiemetics. Integrative therapeutic approaches in addition to standard pharmacologic antiemetic regimes offer potential to control CINV. The purpose of this review was to identify current evidence on integrative therapeutic approaches for the control of CINV in children with cancer. |
|---|---|
| Methods | Online search engines (PubMed, CINAHL, PsychINFO) were queried using MESH terms. Titles, abstracts, and then full-text articles were reviewed for relevance to the review. |
| Results | The search resulted in 53 studies. Twenty-one studies met our review criteria. Integrative therapies identified included acupuncture/acupressure, aromatherapy, herbal supplements, hypnosis, and other cognitive behavioral interventions. Our review identified little information on the effectiveness and safety of most integrative therapeutic approaches for the control and management of CINV in children with cancer. |
| Conclusions | However, evidence from adult cancer studies and some pediatric studies identify promising interventions for further testing. |
2. Clinical Practice Guidelines
| ⊕ positive recommendation (regardless of the level of evidence reported) Ø negative recommendation (or lack of evidence) |
2.1. 6th and 7th International consensus guidelines for the management of advanced breast cancer 2023 ⊕
Cardoso F, Paluch-Shimon S, Schumacher-Wulf E, Matos L, Gelmon K, Aapro MS, Bajpai J, Barrios CH, Bergh J, Bergsten-Nordström E, Biganzoli L, Cardoso MJ, Carey LA, Mac Gregor MC, Chidebe R, Cortés J, Curigliano G, Dent RA, El Saghir NS, Eniu A, Fallowfield L, Francis PA, Franco Millan SX, Gilchrist J, Gligorov J, Gradishar WJ, Haidinger R, Harbeck N, Hu X, Kaur R, Kiely B, Kim SB, Koppikar S, Kuper-Hommel MJJ, Lecouvet FE, Mason G, Mertz SA, Mueller V, Myerson C, Neciosup S, Offersen BV, Ohno S, Pagani O, Partridge AH, Penault-Llorca F, Prat A, Rugo HS, Senkus E, Sledge GW, Swain SM, Thomssen C, Vorobiof DA, Vuylsteke P, Wiseman T, Xu B, Costa A, Norton L, Winer EP. 6th and 7th International consensus guidelines for the management of advanced breast cancer (ABC guidelines 6 and 7). Breast. 2024 May 28;76:103756. https://doi.org/10.1016/j.breast.2024.103756
| Acupuncture may help against chemotherapy-induced nausea and vomiting, fatigue and hot flushes. (Level of Evidence 1/ b; Consensus 100%) |
2.2. Multinational Association of Supportive Care in Cancer and the European Society for Medical Oncology (MASCC, ESMO) 2023 ⊕
| Acupuncture and electroacupuncture.The use of acupuncture or electroacupuncture, where appropriate and as an adjunct to standard antiemetics, is suggested for the management of CINV, particularly acute vomiting. Any effects may be short-lived [II, B]. Acupressure and auricular acupressure. No recommendation can be made for the use of acupressure or auricular acupressure due to conflicting evidence, while the use of non-invasive electrical stimulation is not recommended [III, C]. |
2.3. National Cancer Comprehensive Network (NCCN, USA) 2022 ⊕
NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Antiemesis Version 2.2022 — March 23, 2022. https://www.nccn.org/professionals/physician_gls/pdf/antiemesis.pdf
| Anticipatory nausea/vomiting : Acupuncture/acupressure. |
2.4. Sociedad Española de Oncología Médica (SEOM, Spain) 2022 ⊕
Majem M, de Las Peñas R, Virizuela JA, Cabezón-Gutiérrez L, Cruz P, Lopez-Castro R, Méndez M, Mondéjar R, Muñoz MDM, Escobar Y. SEOM clinical guideline emesis (2021). Clin Transl Oncol. 2022 Mar 26. https://doi.org/10.1007/s12094-022-02802-1
| Other therapies such as acupuncture have been shown to be efective in controlling anticipatory emesis (Evidence level II; Recommendation grade B). |
2.5. Association of the Scientific Medical Societies, German Cancer Society, German Cancer Aid, (AWMF, DKG, DK, Germany) 2021 ⊕
S3-Leitlinie Komplementärmedizin in der Behandlung von onkologischen PatientInnen. September 2021. https://www.leitlinienprogramm-onkologie.de/leitlinien/komplementaermedizin/
| 11.3.1.12. Nausea and vomiting. Acupressure. Recommendation strength: Can. Patient context: Oncological patients. Note: (Chemo- or radiotherapy induced). Acupuncture. Recommendation strength: Can. Patient context: Patients with platinum-based chemotherapy. Note: In addition to antiemetic therapy (chemotherapy induced). |
2.6. American Society of Clinical Oncology (ASCO, USA) 2020 Ø
Hesketh PJ, Kris MG, Basch E, Bohlke K, Barbour SY, Clark-Snow RA, Danso MA, Dennis K, Dupuis LL, Dusetzina SB, Eng C, Feyer PC, Jordan K, Noonan K, Sparacio D, Lyman GH. Antiemetics: ASCO Guideline Update J Clin Oncol.. 2020;38(24):2782-2797. [211193]. doi
| Evidence remains insufficient for a recommendation for or against the use of ginger, acupuncture/acupressure, and other complementary or alternative therapies for the prevention of nausea and vomiting in patients with cancer. |
2.7. National Cancer Comprehensive Network (NCCN, USA) 2020 ⊕
NCCN. Clinical Practice Guidelines in Oncology (NCCN guidelines for patient): Guidelines for Supportive Care : Antiemesis. Version 1.2021. National Cancer Comprehensive Network. 2020;:71P. doi
| Anticipatory nausea/vomiting : acupuncture/acupressure. |
2.8. Arbeitsgemeinschaft Gynäkologische Onkologie (AGO, Allemagne) 2018 ⊕
Diagnosis and Treatment of Patients with Primary and Metastatic Breast Cancer. Complementary Therapy Survivorship. Arbeitsgemeinschaft Gynäkologische Onkologie (AGO). 2018;:35P. [182073].
| (Electro)-Acupuncture as adjunct to entiemetic treatment in case of Chemotherapy-induced nausea and vomiting. Level of evidence : 1b (individual RCT), grade of evidence (B), AGO recommendation grade (+) This examination or therapeutic intervention is for the patient of limited benefit and can be performed. |
2.9. National Cancer Comprehensive Network (NCCN, USA) 2018 ⊕
NCCN Guidelines for Supportive Care : antiemesis. National Cancer Comprehensive Network. 2018;:68P. [188079].
| Anticipatory nausea/vomiting : acupuncture/acupressure. |
2.10. American Cancer Society / American Society of Clinical Oncology (ASCO, USA) 2018 ⊕
Lyman GH, Greenlee H, Bohlke K, Bao T, DeMichele AM, Deng GE, Fouladbakhsh JM, Gil B, Hershman DL, Mansfield S, Mussallem DM, Mustian KM, Price E, Rafte S, Cohen L. Integrative Therapies During and After Breast Cancer Treatment: ASCO Endorsement of the SIO Clinical Practice Guideline. J Clin Oncol. 2018;Jun 11. [155475].
| Chemotherapy‐induced nausea and vomiting Recommendations: Acupressure can be considered as an addition to antiemetics drugs to control nausea and vomiting during chemotherapy (Strength of evidence : B). Electroacupuncture can be considered as an addition to antiemetics drugs to control vomiting during chemotherapy (Strength of evidence : B) |
2.11. European School of Oncology (ESO) and the European Society for Medical Oncology (ESMO) 2018 ⊕
Cardoso F, Senkus E, Costa A, Papadopoulos E, Aapro M, André F et al. 4th ESO-ESMO International Consensus Guidelines for Advanced Breast Cancer (ABC 4)†. Ann Oncol. 2018;29(8):1634-57. [196973].
| Acupuncture may help against induced nausea and vomiting, fatigue and hot flashes; |
2.12. Aetna (insurance provider, USA) 2018 ⊕
Acupuncture. Aetna (insurance provider, USA). 2018. 73P. [188029].
| Aetna considers needle acupuncture (manual or electroacupuncture) medically necessary for any of the following indications:chemotherapy-induced nausea and vomiting |
2.13. Alberta Health Services 2017 (AHS, Canada) ⊕
Chemotherapy Induced Nausea and Vomiting, Pediatric – Inpatient, Provincial Clinical Knowledge Topic. Alberta Health Services. 2017. 42p. [173086].
| Consider using breakthrough CINV interventions : Acupressure or acupuncture. |
2.14. American Society of Clinical Oncology (ASCO, USA) 2017 Ø
Hesketh PJ, Kris MG, Basch E, Bohlke K, Barbour SY, Clark-Snow RA, Danso MA, Dennis K, Dupuis LL, Dusetzina SB, Eng C, Feyer PC, Jordan K, Noonan K, Sparacio D, Somerfield MR, Lyman GH. Antiemetics: American Society of Clinical Oncology clinical practice guideline update. J Clin Oncol. 2017;35(28):3240-61. [197509].
| Complementary and alternative therapies: (Reworded for clarity) Evidence remains insufficient for a recommendation for or against the use of ginger, acupuncture/acupressure, and other complementary or alternative therapies for the prevention of nausea and vomiting in patients with cancer. |
2.15. Association Francophone des Soins Oncologiques de Support (AFSOS, France) 2017 ⊕
Association Francophone des Soins Oncologiques de Support (AFSOS). Fiches Réferentiels ; Prise en charge des vomissements chimio-induits (MAJ 2017). [196582].
| NVCI. Solutions non-médicamenteuses: acupuncture. En complément d'une prophylaxie médicamenteuse bien conduite (grade B de recommandation) |
2.16. British Columbia Cancer Agency (BCCA, Canada) 2017 ⊕
Palliative Care for the Patient with Incurable Cancer or Advanced Disease Part 2: Pain and Symptom Management . Clinical Practice Guidelines and Protocols in British Columbia. 2017:47P. [197157].
| Nausea and Vomiting: Non-pharmacological: modifications to diet (e.g., small bland meals) and environment (e.g., control smells and noise), relaxation and good oral hygiene, and acupressure (for chemotherapy-induced acute nausea, but not for delayed. |
2.17. Society for Integrative Oncology (SIO, USA) 2017 ⊕
Greenlee H, DuPont-Reyes MJ, Balneaves LG et al. Clinical practice guidelines on the evidence-based use of integrative therapies during and after breast cancer treatment. CA Cancer J Clin. 2017 May 6;67(3):194-232. [158977].
| Chemotherapy‐Induced Nausea and Vomiting : Acupressure can be considered as an addition to anti-emetics drugs to control nausea and vomiting during CT.(Strength of evidence : B) Acupuncture can be considered as an addition to anti-emetics drugs to control vomiting during CT.(Strength of evidence : B) |
2.18. Emblemhealth (insurance provider, USA) 2017 ⊕
Acupuncture — Medicare Dual-Eligible Members Emblemhealth. 2017. [111547].
| Members with the Medicare Dual-Eligible benefit are eligible for acupuncture when performed by an individual licensed by New York State to perform acupuncture and when performed for the following diagnoses: 1. Adult postoperative nausea and vomiting 2. Chemotherapy related nausea and vomiting 3. Pregnancy related nausea and vomiting 4. Carpal tunnel syndrome 5. Epicondylitis (tennis elbow) 6. Headache 7. Low back pain 8. Menstrual pain 9. Myofascial pain 10. Osteoarthritis |
2.19. Ministry of Health (MOH, Malaysia) 2017 ⊕
Traditional and Complementary Medicine Practice Guideline on Acupuncture. Traditional and Complementary Medicine (T&CM) Division, Ministry of Health (MOH). Kuala Lumpur, Malaysia. 2017. 41p. [180540].
| Acupuncture services offered at the T&CM Units of public healthcare facilities are indicated for: a) Post stroke management; b) Chronic pain management; and c) Chemotherapy-induced nausea and vomiting. |
2.20. Society for Integrative Oncology (SIO, USA) 2014 ⊕
Greenlee H, Balneaves LG, Carlson LE, Cohen M, Deng G, Hershman D, Mumber M, Perlmutter J, Seely D, Sen A, Zick SM, Tripathy D; Society for Integrative Oncology. Clinical practice guidelines on the use of integrative therapies as supportive care in patients treated for breast cancer. J Natl Cancer Inst Monogr. 2014;50:346-58. [167074].
| CINV. Recommendations: Acupressure can be considered for BC patients receiving CT as an addition to antiemetics to help control nausea and vomiting during CT. Electroacupuncture can be considered for BC patients as an addition to antiemetics to control vomiting during CT Strength of evidence: B |
2.21. Association Francophone des Soins Oncologiques de Support (AFSOS) 2014 ⊕
Association Francophone des Soins Oncologiques de Support (AFSOS). Fiches Réferentiels : L’acupuncture en onco-hématologie MAJ 2014 (online)
| Nausées et vomissements chimio-induits (N/V). L'acupuncture est indiquée en complément des traitements conventionnels dans la prise en charge des N/V induits par la chimiothérapie, en particulier les N/V aigus. Peu de données évaluent l'acupuncture dans les N/VN retardés. Les traitements conventionnels utilises et décrits dans la littérature ne font pas référence aux traitements de dernière génération (anti NK1 type aprepitant) (Niveau de preuve HAS : A) |
2.22. European Partnership for Action Against Cancer (EPAA, Europe) 2014 ⊕
Complementary and alternative medicine (CAM) in cancer care. Development and opportunities of Integrative Oncology. European Partnership for Action Against Cancer (EPAAC). 2014;:339P. [186081].
| As to the use of acupuncture and TCM in the treatment of symptoms correlated to anti-cancer therapy, the literature has demonstrated a good level of evidence in the following cases: nausea and vomiting, pain, hotflashes and xerostomia, taking also in account the absence of relevant adverse effects and interactions. |
2.23. American College of Chest Physicians (ACCP, USA) 2013 ⊕
Deng GE, Rausch SM, JoneS LW, Gulati A, Kumar NB, GreenleE H, Pietanza MC, Cassileth BR. Complementary therapies and integrative medicine in lung cancer: diagnosis and management of lung cancer, 3rd ed: American College Of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2013;143(5 Suppl):420-36. [159371].
| Recommendation 2.5.3.1. In patients having nausea and vomiting from either chemotherapy or radiation therapy, acupuncture or related techniques is suggested as an adjunct treatment option (Grade 2B). |
2.24. U.S. Navy Bureau of Medicine and Surgery (USA) 2013 ⊕
Acupuncture. U.S. Navy Bureau of Medicine and Surgery. 2013.17p. [180539].
| Category A (fair to high quality evidence): Authorized and recommended for routine use. Chemotherapy induced nausea/vomiting . |
2.25. Pediatric Oncology Group of Ontario (POGO, Canada) 2012 ⊕
Dupuis LL, Boodhan S, Holdsworth M, Robinson PD, Hain R, Portwine C, O'Shaughnessy E, Sung L. Guideline for the prevention of acute nausea and vomiting due to antineoplastic medication in pediatric cancer patients. Toronto (ON): Pediatric Oncology Group of Ontario (POGO); 2012. 199 p. [155232].
| What adjunctive non-pharmacological interventions provide control of acute AINV in children receiving antineoplastic agents of any emetic risk? Recommendation: We suggest that acupuncture, acupressure, guided imagery, music therapy, progressive muscle relaxation and psycho-educational support and information may be effective in children receiving antineoplastic agents. Virtual reality may convey benefit. (Weak recommendation Very low quality evidence) |
2.26. American Society of Clinical Oncology (ASCO, USA) 2011 Ø
Basch E, Prestrud AA, Hesketh PJ, et al. Antiemetics: American Society of Clinical Oncology clinical practice guideline update. J Clin Oncol. 2011;29(31):4189-98. [157361]
| Recommendation 7. No published randomized controlled trial data that met inclusion criteria are currently available to support a recommendation about such therapies [complementary and alternative medicine therapies]. A Cochrane Systematic Review of acupuncture-point stimulation for CINV was published [Ezzo 2006]. However, this effort did not meet prespecified inclusion and exclusion criteria for this systematic review. |
2.27. American College of Chest Physicians (ACCP, USA) 2007 ⊕
Cassileth BR, Deng GE, Gomez JE, Johnstone PA, Kumar N, Vickers AJ; American College of Chest Physicians. Complementary therapies and integrative oncology in lung cancer: Accp Evidence-Based Clinical Practice Guidelines (2nd Edition). Chest. 2007;132(3sup:340s-54s. [146961]
| Recommendation 8. Acupuncture is recommended as a complementary therapy when nausea and vomiting associated with chemotherapy are poorly controlled. Grade of recommendation, 1B Recommendation 9. Electrostimulation wristbands are not recommended for managing chemotherapy-induced nausea and vomiting. Grade of recommendation, 1B |
2.28. National Institute for Health and Clinical Excellence (NICE, UK) 2004 ⊕
Guidance on Cancer Services Improving Supportive and Palliative Care for Adults with Cancer. National Institute for Health and Clinical Excellence - Clinical Guidelines. 2004:209P. [197445].
| There have been three systematic reviews of randomised controlled trials and studies of other complementary therapies, not limited exclusively to patients with cancer. Two provide some evidence of the benefits of aromatherapy in reducing anxiety [A] and acupuncture in reducing nausea and vomiting [A]. Preliminary results of a systematic review 152 11 of chemotherapy-related nausea and vomiting is also positive for acupuncture14 [A]. There is some indication that therapies might have the ability to improve patients’ general sense of well-being and quality of life through, for instance, reductions in distress, anxiety, pain and nausea [B]. |
3. Randomized Controlled Trials
3.1. Sources
Tous les ECR listés sont répertoriés dans la base de données Acudoc2. Les citations des ECR dans les revues systématiques et recommandations de bonne pratique sont rapportées dans le tableau ci-dessous. La mention Acudoc2 indique que l'ECR n'est pas cité, actuellement, par une revue systématique ou recommandation de bonne pratique.
Revues systématiques
- Lian 2014: Lian WL, Pan MQ, Zhou DH, Zhang ZJ. Effectiveness of acupuncture for palliative care in cancer patients: a systematic review. Chin J Integr Med. 2014.20(2):136-47
- Mvkeon 2013: Mckeon C, Smith CA, Hardy J, Chang E. Acupuncture and acupressure for chemotherapy-induced nausea and vomiting: a systematic review. Aust J Acupunct Chin Med. 2013. 8(1):2-27. [160092].
- Garcia 2013: Garcia MK, Mcquade J, Haddad R, Patel S, Lee R, Yang P, Palmer JL, Cohen L. Systematic review of acupuncture in cancer care: a synthesis of the evidence. J Clin Oncol. 2013. 31(7):952-60.
- Silva 2009 : Silva, Dacirene Ribeiro França; Reis, Paula Elaine Diniz; Gomes, Isabelle Pimentel Gomes; Funghetto, Silvana Schwerz; Ponce de Leon, Casandra G. R. M. [Non Pharmacological Interventions for Chemotherapy Induced Nauseas and Vomits: integrative review]. Online Brazilian Journal of Nursing. 2009;8(1).
- Ezzo 2006: Ezzo JM, Richardson MA, Vickers A, Allen C, Dibble SL, Issell BF, Lao L, Pearl M, Ramirez G, Roscoe J, Shen J, Shivnan JC, Streitberger K, Treish I, Zhang G. Acupuncture-point stimulation for chemotherapy-induced nausea or vomiting. Cochrane Database Syst Rev. 2006;(2):CD002285.141212
- Klein 2004: Klein J, Griffiths P. Acupressure for nausea and vomiting in cancer patients receiving chemotherapy, British Journal of Community Nursing. 2004. 9(9):383-88. [159378].
Recommandations de bonne pratique
- ASCO 2018: Lyman GH, Greenlee H, Bohlke K, Bao T et al. Integrative Therapies During and After Breast Cancer Treatment: ASCO Endorsement of the SIO Clinical Practice Guideline. J Clin Oncol. 2018 Jun 11:JCO2018792721. doi: 10.1200/JCO.2018.79.2721.
- ASCO 2017: Hesketh PJ, Kris MG, Basch E, Bohlke K, Barbour SY, Clark-Snow RA, Danso MA, Dennis K, Dupuis LL, Dusetzina SB, Eng C, Feyer PC, Jordan K, Noonan K, Sparacio D, Somerfield MR, Lyman GH. Antiemetics: American Society of Clinical Oncology Clinical Practice Guideline Update. J Clin Oncol. 2017;35(28):3240-61. [187938].
- SIO 2014: Greenlee H, Balneaves LG, Carlson LE, Cohen M, Deng G, Hershman D, Mumber M, Perlmutter J, Seely D, Sen A, Zick SM, Tripathy D; Society for Integrative Oncology. Clinical practice guidelines on the use of integrative therapies as supportive care in patients treated for breast cancer. J Natl Cancer Inst Monogr. 2014;50:346-58. [167074].
- ACCP 2013: Deng GE, Rausch SM, JoneS LW, Gulati A, Kumar NB, GreenleE H, Pietanza MC, Cassileth BR. Complementary therapies and integrative medicine in lung cancer: diagnosis and management of lung cancer, 3rd ed: American College Of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2013;143(5 Suppl):420-36. [159371].
- ACCP 2007: Cassileth BR, Deng GE, Gomez JE, Johnstone PA, Kumar N, Vickers AJ; American College of Chest Physicians. Complementary therapies and integrative oncology in lung cancer: Accp Evidence-Based Clinical Practice Guidelines (2nd Edition). Chest. 2007;132(3sup:340s-54s. [146961]
3.2. List
| Année | Références | Sources |
|---|---|---|
| 2017 | Feng Xiumei. [Clinical effect of acupuncture combined with acupoint massage on gastrointestinal reaction after chemotherapy in patients with breast cancer]. Journal of Modern Oncology. 2017;18:2922-5. [195857]. | Acudoc2 |
| Pu Zhong-Jian, Ma Xiao-Ping, Wang Ya-Jun, Sun Yuan-Peng. [Clinical Study on Different Acupuncture and Moxibustion Methods for Prevention and Treatment of Nausea and Vomiting Caused by Chemotherapy]. Chinese Journal of Information on Traditional Chinese Medicine. 2017;3:34-7. [195902]. | Acudoc2 | |
| Xie J, Chen LH, Ning ZY, Zhang CY, Chen H, Chen Z, Meng ZQ, Zhu XY. Effect of transcutaneous electrical acupoint stimulation combined with palonosetron on chemotherapy-induced nausea and vomiting: a single-blind, randomized, controlled trial. Chin J Cancer. 2017;36(1):6. [166182] | Acudoc2 | |
| 2016 | Avc HS, Ovayolu N, Ovayolu Ö. Effect of Acupressure on Nausea-Vomiting in Patients With Acute Myeloblastic Leukemia. Holist Nurs Pract. 2016;30(5):257-62. [187817]. | Acudoc2 |
| Eghbali M, Yekaninejad MS, Varaei S, Jalalinia SF Samimi MA, Sa'atchi K. The effect of auricular acupressure on nausea and vomiting caused by chemotherapy among breast cancer patients. Complement Ther Clin Pract. 2016;:189-94. [188511]. | Acudoc2 | |
| Hu Cuilian, Chen Chunyan, Wei Shuli. [The result detection of decreasing tumor chemotherapy by ear beans pressure and tsusanli acupuncture point acupoint injection]. Chinese Journal of Ethnomedicine and Ethnopharmacy. 2016;3:78-9. [52045]. | Acudoc2 | |
| Liu Hong , Xu Tian-shu. [Clinical Study on Moxibustion Treatment for Nausea and Vomiting Induced by Cisplatin Clemotherapy] Journal of Clinical Acupuncture and Moxibustion. 2016;32(11):4. [188600]. | Acudoc2 | |
| Xie Anwei, Niu Meie, Chan Yuying, Xu Yueye, Hu Shaoyan, Lin Xiaoxia. [Effect observation for Acupuncture therapy for chemotherapy-induced gastrointestinal reaction in children with acute leukemia]. Journal of Nurses Training. 2016;6:488-91. [195876] | Acudoc2 | |
| Xu Yin, Cheng Yongbo, Liu Li’ning, Yang Zhijun, An Junli, Handan Mingren Hospital. [Clinical Observation of Prevention for Gastrointestinal Symptoms Caused by Chemotherapy(Cisplatin) with Old Ten-Needles]. Chinese Archives of Traditional Chinese Medicine. 2016;2:359-61. [52068]. | Acudoc2 | |
| 2015 | Chen Yan. [Observation on the clinical effect of mine fire moxibustion on the prevention of chemotherapy induced vomiting]. Dazhong Keji. 2015;8:99-101. [195933]. | Acudoc2 |
| Lai Milin, Liu Dan. [An Observation on Effect of Bo's Abdominal Acupuncture on Nausea and Vomiting after Chemotherapy for Breast Cancer]. Journal of Mathematical Medicine. 2015;9:1295-6. [52017] | Acudoc2 | |
| Liang Xiaoning. [Prevention efficacy watch of Xiexin ginger decoction combined with acupuncture and vomiting after chemotherapy]. Dazhong Keji. 2015;6:97-8. [52067]. | Acudoc2 | |
| Liu Jun, Xiao Yang, Guo Jianxiong, Liu Yangchen, Wei Wei, Zhou Juan. [Clinical trial of electronic antiemetic acupuncture in combination with palonosetron in prevention of tardive vomiting induced by highly emetogenic chemotherapy]. Chongqing Medical Journal. 2015;8:1087-90. [52106]. | Acudoc2 | |
| Liu YQ, Sun S, Dong HJ, Zhai DX1, Zhang DY, Shen W, Bai LL, Yu J, Zhou LH, Yu CQ. Wrist-ankle acupuncture and ginger moxibustion for preventing gastrointestinal reactions to chemotherapy: A randomized controlled trial. Chin J Integr Med. 2015;21(9):697-702. [186899] | Acudoc2 | |
| Mckeon C, Smith Ca, Gibbons K, Hardy J. EA versus sham acupuncture and no acupuncture for the control of acute and delayed chemotherapy-induced nausea and vomiting: a pilot study. Acupunct Med. 2015;33(4):277-83. [185627]. | Acudoc2 | |
| Rithirangsriroj K, Manchana T, Akkayagorn L. Efficacy of acupuncture in prevention of delayed chemotherapy induced nausea and vomiting in gynecologic cancer patients. Gynecol Oncol. 2015;136(1):82-6. [178355]. | ASCO 2017 | |
| Shen Y, Liu L, Chiang Js, Meng Z, Garcia Mk, Chen Z, Peng H, Bei W, Zhao Q, Spelman AR, Cohen L. randomized, placebo-controlled trial of K1 acupoint acustimulation to prevent cisplatin-induced or oxaliplatin-induced nausea. Cancer. 2015;121(1):84-92. [178360]. | Acudoc2 | |
| Tang Yanqing, Ma Hongmei, Wan Yonghui, Chen Sanmei, Renmin Hospital of Wuhan University. [Clinical observation of electronic antiemetic acupuncture combined with tropisetron in the prevention of vomiting induced by cisplatin chemotherapy]. Journal of Modern Oncology. 2015;17:2491-4. [52218]. | Acudoc2 | |
| 2014 | Molassiotis A, Russell W, Hughes J, Breckons M, Lloyd-Williams M, Richardson J, Hulme C, Brearley SG, Campbell M, Garrow A, Ryder WD. The effectiveness of acupressure for the control and management of chemotherapy-related acute and delayed nausea: a randomized controlled trial. J Pain Symptom Manage. 2014;47(1):12-25. [42611]. | ASCO 2017 |
| Wang Li-Na, Hu Hong-Yan, Qiu Yi-Ling, et al. Acupoint sticking at shenque (CV 8) with ginger-prepared ban xia (rhizoma pinelliae) for nausea and vomiting induced by amifostine. Journal of Acupuncture and Tuina Science. 2014;12(4):221. [187074]. | Acudoc2 | |
| 2013 | Genç A, Can G, Aydiner A. The efficiency of the acupressure in prevention of the chemotherapy-induced nausea and vomiting. Support Care Cancer. 2013;21(1):253-61. [42617]. | ASCO 2017 |
| Xing Jin-Yun, Li Xue, Ren Xiu-Mei. [Therapeutic observation of abdominal acupuncture in preventing nausea and vomiting caused by cisplatin-based chemotherapy]. Shanghai Journal of Acupuncture and Moxibustion. 2013;32(12):1046. [178935]. | Acudoc2 | |
| 2012 | Beith JM, Oh B, Chatfield MD, et al. Electroacupuncture for nausea, vomiting, and myelosuppression in women receiving adjuvant chemotherapy for early breast cancer: a randomized controlled pilot trial. Medical Acupuncture. 2012;24():241-8. [48548]. | SIO 2014 |
| Enblom A, Johnsson A, Hammar M, Onelöv E, Steineck G, Börjeson S. Acupuncture compared with placebo acupuncture in radiotherapy-induced nausea, a randomized controlled study. Annals of Oncology. 2012;23(5):1353-61. [160110]. | ASCO 2017 - Garcia 2013 - ACCP 2013 | |
| Yeh CH, Chien LC, Chiang YC, Lin SW, Huang CK, Ren D. Reduction in nausea and vomiting in children undergoing cancer chemotherapy by either appropriate or sham auricular acupuncture points with standard care. J Altern Complement Med. 2012;18(4):334-40. [160068]. | Acudoc2 | |
| 2009 | Sima L, Wang X. [Therapeutic effect of acupuncture on cisplatin-induced nausea and vomiting]. Zhongguo Zhen Jiu. 2009;29(1):3-6. [152395]. | ACCP 2013 |
| Yang Y, Zhang Y, Jing NC, et al. Electroacupuncture at Zusanli (ST 36) for treatment of nausea and vomiting caused by the chemotherapy of the malignant tumor: a multicentral randomized controlled trial [in Chinese]. Zhongguo Zhen Jiu. 2009;29(12):955-958 [154625]. Traduction anglaise International Journal of Clinical Acupuncture. 2010;2:53-59. [162878]. | Lian 2014 - ACCP 2013 - Garcia 2013 - | |
| You Q, Yu H, Wu D, Zhang Y, Zheng J, Peng C. Vitamin B6 points pc6 injection during acupuncture can relieve nausea and vomiting in patients with ovarian cancer. Int J Gynecol Cancer. 2009;19(4):567-71. [153307]. | ACCP 2013 | |
| 2008 | Gottschling S, Reindl TK, Meyer S, Berrang J, Henze G, Graeber S, Ong MF, Graf N. Acupuncture to alleviate chemotherapy-induced nausea and vomiting in pediatric oncology - a randomized multicenter crossover pilot trial. Klin Padiatr. 2008;220(6):365-70. [152496]. | ACCP 2013 - Garcia 2013 - Mckeon 2013 |
| Jones E, Isom S, Kemper KJ, Mclean TW. Acupressure for chemotherapy-associated nausea and vomiting in children. J Soc Integr Oncol. 2008;6(4):141-5. [159475]. | Mckeon 2013 - | |
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